Thanks to Post Human Blues and Sentient Developments for this:

And while I pondering technology and our future, IEET published a piece by Randall Mayes that gets to something about blood substitutes that I didn’t know:

The FDA has placed a number of blood substitutes in clinical trials at selected hospitals for accident victims in the United States which are trauma victims in life threatening situations. Although blood substitutes do not have white blood cells found in whole blood, they have hemoglobin from expired human blood to carry oxygen.

Biopure’s Hemopure failed in the United States, but was approved for use in South Africa. Unfortunately, in the United States the other candidates have either failed or were withdrawn due to side effects including liver and kidney failure, irritated blood vessels, and heart attacks.

The most promising candidate, PolyHeme, was developed by Northfield Laboratories to overcome the drawbacks of working with whole blood. It has a shelf life of over twelve months while stored at room temperature, is purified it to minimize risk of viral disease transmission, and is compatible with all blood types.

In circumstances where a patient at least eighteen years old is in critical condition at the scene of the injury, random patients either received saline solution or PolyHeme for up to twelve hours as needed after transported to selected trauma centers. It was one of the few candidates to complete phase III clinical trials, but it also failed to win approval with an unfavorable risk-benefit assessment.

In 2008, the Journal of American Medical Association released the paper, Cell-Free Hemoglobin Based Blood Substitutes and Risk of Myocardial Infarction and Death, which is a meta-analysis study of 16 clinical trials of blood substitutes, including 5 products, and 3711 patients. The paper was the bearer of bad news as it revealed patients in clinical trials had a 30 percent greater chance of death when compared to a control group.

The Informed Consent Dilemma

Humans are involuntarily used as guinea pigs for blood substitute clinical trials? In 2006, those living in 32 communities in 18 states and anyone traveling through these communities were potential guinea pigs without consent in Polyheme’s Phase III clinical trials. PolyHeme is the fifteenth experiment allowed by the FDA for emergency medical trials exempted from informed consent.

This is disconcerting since one of the distinguishing factors between eugenics and transhumanism is that the H+ movement is based on voluntary use of medical treatments and artificial human enhancements. But, what if someone is incapable of giving informed consent and a blood substitute is the only hope for survival to an accident victim or a soldier?

In order to avoid participating in the clinical trials, citizens had to inform their local testing site and wear a medical bracelet. Although I live several blocks away form the Duke University Medical Center which is one of the trauma centers across the United States which is sanctioned by the FDA, I was not aware of the clinical trials or the exemption procedures.

Even more disturbing, bioethicists Dickert and Sugarman disclosed in the Kennedy Institute of Ethics Journal that Northfield Laboratories was able to withhold proprietary data relating to the trials which remained unpublished because they had no government requirement to report problems . It wasn’t until Public Citizen filed a law suit that FDA released the data.